Translation of "manifestato serie" in English

Translations:

expressed serious

How to use "manifestato serie" in sentences:

Lo studio dimostra che l’incidenza della CKD è di 2360 pmp, cioè circa 1/53 della prevalenza; la diagnosi viene posta quando circa il 40% dei pazienti ha già subito un evento cardiovascolare, quindi ha già manifestato serie complicanze della nefropatia.
The study demonstrate that CKD incidence is 2360 pmp, about 1/53 of the prevalence; diagnosis is made after a cardiovascular event in about 40% of cases, that it means that serious complications of disease have yet established.
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